Early TNF-α levels correlate with ischaemic stroke severity
Objectives– The study aimed to evaluate the levels of an important proinflammatory cytokine tumour necrosis factor-α (TNF-α) in cerebrospinal fluid (CSF) and serum in acute stroke and to study the relation between those and the neurological stroke severity and functional disability. Material and methods– The investigations comprised 23 ischaemic stroke patients. CSF and blood samples were obtained 24 h after the onset of stroke, and stored until analysis. Patients were examined according to Scandinavian Stroke Scale (SSS) and to Barthel Index (BI). Results– The patients displayed statistically significant high levels of TNF-α in CSF and sera within the first 24 h of stroke. These correlated significantly with SSS and BI scores calculated within the same interval, and 1 and 2 weeks later. Conclusion– Our results suggest the involvement of TNF-α in mechanisms of early stroke-induced inflammation and a predictive value of the initial TNF-α levels for the outcome of stroke.