Skip to main content

Loco-regional thrombolysis in the treatment of cerebral venous and sinus thrombosis: report of two cases

Buy Article:

$43.00 plus tax (Refund Policy)

Although intravenous (i.v.) heparin is widely used as the first line treatment for cerebral venous and sinus thrombosis (CVST), the most appropriate therapy for this disease is still controversial. We report 2 cases of CVST who were successfully treated by means of loco-regional thrombolysis with urokinase. In the first case we chose this treatment instead of i.v. heparin because clinical conditions of the patient appeared critical for life on hospital admission; in the second case loco-regional thrombolysis was performed because a full-dose heparin treatment over 8 days failed to improve the clinical picture of the patient. In the literature, there are no established criteria for the use of loco-regional thrombolysis in CVST. On the basis of our own experience and few previous reports on the matter, we suggest that loco-regional thrombolysis should be considered an appropriate treatment for CVST when patients are at life risk, when an involvement of deep cerebral veins is present or when, after full heparinization, patients are doing poorly clinically.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: cerebral venous and sinus thrombosis; rtPA; thrombolysis; urokinase

Document Type: Research Article

Affiliations: 1: Institute of Neurology, University of Parma, Parma, Italy, 2: Medical Division, Hospital of Fidenza, Fidenza, Italy, 3: Division of Neuroradiology, Hospital of Parma, Parma, Italy, 4: Department of Emergency Care, Hospital of Parma, Parma, Italy

Publication date: 2001-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more