Elevation of neuron‐specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt-Jakob disease

Authors: Kohira, I.¹; Tsuji, T.²; Ishizu, H.³; Takao, Y.⁴; Wake, A.⁵; Abe, K.¹; Kuroda, S.³

Source: Acta Neurologica Scandinavica, Volume 102, Number 6, December 2000 , pp. 385-387(3)

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Abstract:

Objective- To investigate the levels of neuron‐specific enolase (NSE) in serum and cerebrospinal fluid (CSF) of patients with early stage Creutzfeldt-Jakob disease (CJD). Methods- The levels of NSE in serum and CSF were examined in 6 cases with CJD patients. The levels of NSE in CSF were measured in 8 age matched control patients with other neurological diseases and the levels of serum NSE were also measured in another 8 age matched control patients with other neurological diseases. The groups of 8 age matched control patients consisted of 1 same patient and 7 different patients in the 2 control groups both for serum and CSF. Results- The level of serum NSE in CJD (17.3±7.0 ng/ml, mean±SD) was significantly higher than that of controls (6.5±1.6) (P<0.02) as was the case in CSF (79.3±53.3 ng/ml) vs (9.6±2.9) (P<0.03). Conclusion- Although mean NSE levels of CJD were higher in CSF than in the serum, there still is a case with higher serum NSE level than CSF. These results suggest that the mechanism of elevation of serum NSE may not be a simple leakage from CSF, and that the measurement of serum NSE level may be useful for diagnosis of early stage CJD.

Keywords: Creutzfeldt-Jakob disease (CJD); neuron‐specific enolase (NSE); serum; cerebrospinal fluid (CSF); dementia

Document Type: Short communication

DOI: http://dx.doi.org/10.1034/j.1600-0404.2000.102006385.x

Affiliations: 1: Department of Neurology, Okayama University Medical School, 2: Kyokuto Hospital, 3: Department of Neuropsychiatry, Okayama University Medical School, 4: Kurashiki Heisei Hospital, 5: Takahashi Hospital

Publication date: 2000-12-01

Elevation of neuron‐specific enolase in serum and cerebrospinal fluid of early stage Creutzfeldt-Jakob disease

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