Skip to main content

SPECT in Alzheimer's disease:features associated with bilateral parietotemporal hypoperfusion

Buy Article:

$43.00 plus tax (Refund Policy)

Abstract

Objective– To investigate why bilateral parietotemporal hypoperfusion, the typical SPECT pattern of Alzheimer's disease (AD), occurs in some but not in all patients with probable AD. Methods– We reviewed the SPECT scans of 220 patients presenting with cognitive impairment. Among them, 104 patients fulfilled NINCDS–ADRDA criteria for probable AD, 48 (32 women) with early onset (before age of 65) and 56 (40 women) with late onset of the symptoms. Dementia severity was assessed by the Mini‐Mental State Examination. The SPECT scans were classified by visual inspection blind to clinical diagnoses. Results– Bilateral parietotemporal hypoperfusion was more frequent in patients with severe AD, in those with early onset of the symptoms, and in men. Duration of symptoms, type of gamma‐camera or radiopharmaceutical agent used were not associated with this SPECT pattern. Conclusion– These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Alzheimer's disease; SPECT; age at onset; dementia

Document Type: Original Article

Affiliations: 1: Neurology, 2: Radiology, and 3: Preventive Medicine, University of São Paulo School of Medicine, Brazil

Publication date: 2000-03-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more