Noninvasive methods for assessment of airway inflammation in occupational settings

Authors: Quirce, S.; Lemière, C.¹; de Blay, F.²; del Pozo, V.; Gerth Van Wijk, R.³; Maestrelli, P.⁴; Pauli, G.²; Pignatti, P.⁵; Raulf-Heimsoth, M.⁶; Sastre, J.; Storaas, T.⁷; Moscato, G.⁵

Source: Allergy, Volume 65, Number 4, April 2010 , pp. 445-458(14)

Publisher: Wiley-Blackwell

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Abstract:

To cite this article: Quirce S, Lemière C, de Blay F, del Pozo V, Gerth Van Wijk R, Maestrelli P, Pauli G, Pignatti P, Raulf-Heimsoth M, Sastre J, Storaas T, Moscato G. Noninvasive methods for assessment of airway inflammation in occupational settings. Allergy 2010; 65: 445-458. Abstract

The present document is a consensus statement reached by a panel of experts on noninvasive methods for assessment of airway inflammation in the investigation of occupational respiratory diseases, such as occupational rhinitis, occupational asthma, and nonasthmatic eosinophilic bronchitis. Both the upper and the lower airway inflammation have been reviewed and appraised reinforcing the concept of `united airway disease' in the occupational settings. The most widely used noninvasive methods to assess bronchial inflammation are covered: induced sputum, fractional exhaled nitric oxide (FeNO) concentration, and exhaled breath condensate. Nasal inflammation may be assessed by noninvasive approaches such as nasal cytology and nasal lavage, which provide information on different aspects of inflammatory processes (cellular vs mediators). Key messages and suggestions on the use of noninvasive methods for assessment of airway inflammation in the investigation and diagnosis of occupational airway diseases are issued.

Keywords: asthma; eosinophils; exhaled breath condensate; fractional exhaled nitric oxide; induced sputum; occupational respiratory diseases; rhinitis

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1398-9995.2009.02274.x

Affiliations: 1: Department of Chest Medicine, Hôpital du Sacré-Coeur, Montreal, Canada 2: Division of Asthma and Allergy, Department of Chest Diseases, University Hospital Strasbourg, France 3: Section of Allergology, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands 4: Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy 5: Allergy and Immunology Unit, Fondazione Salvatore Maugeri, Institute of Care and Research, Scientific Institute of Pavia & Occupational Immunology and Allergy Laboratory ISPESL, Pavia, Italy 6: BGFA - Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Bochum, Germany 7: Department of Otolaryngology, Head & Neck Surgery and Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway

Publication date: 2010-04-01

Noninvasive methods for assessment of airway inflammation in occupational settings

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