Epinephrine: the drug of choice for anaphylaxis. A statement of the World Allergy Organization

Authors: Kemp, S. F.¹; Lockey, R. F.²; Simons, F. E. R.³

Source: Allergy, Volume 63, Number 8, August 2008 , pp. 1061-1070(10)

Buy & download fulltext article:

Price: $48.00 plus tax (Refund Policy)

Abstract:

Anaphylaxis is an acute and potentially lethal multi-system allergic reaction. Most consensus guidelines for the past 30 years have held that epinephrine is the drug of choice and the first drug that should be administered in acute anaphylaxis. Some state that properly administered epinephrine has no absolute contraindication in this clinical setting. A committee of anaphylaxis experts assembled by the World Allergy Organization has examined the evidence from the medical literature concerning the appropriate use of epinephrine for anaphylaxis. The Committee strongly believes that epinephrine is currently underutilized and often dosed suboptimally to treat anaphylaxis, is under-prescribed for potential future self-administration, that most of the reasons proposed to withhold its clinical use are flawed, and that the therapeutic benefits of epinephrine exceed the risk when given in appropriate i.m. doses.

Keywords: anaphylaxis; epinephrine; management; prevention

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1398-9995.2008.01733.x

Affiliations: 1: Department of Medicine, The University of Mississippi Medical Center, Jackson, MS, USA 2: Department of Internal Medicine, University of South Florida College of Medicine and the James A. Haley Veterans' Hospital,Tampa, FL, USA 3: Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Publication date: 2008-08-01