Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency

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Abstract:

Peanut allergy is a severe and life-threatening form of food allergy. Treatments are being developed but the mainstays of current management remain avoidance of peanut and appropriate use of rescue medication. We report the case of a boy with peanut allergy who required a bone marrow transplant (BMT) for combined immunodeficiency. A food challenge, 2 years after transplant, showed that his peanut allergy had resolved. Allergic disorders constitute a form of immune deviation and while we do not advocate BMT as a treatment for peanut allergy, we believe this case provides an insight into the basic mechanisms involved in food allergy.

Keywords: bone marrow transplantation; immunodeficiency; peanut allergy

Document Type: Short Communication

DOI: http://dx.doi.org/10.1111/j.1398-9995.2005.00752.x

Affiliations: 1: Division of Infection, Inflammation and Repair, University of Southampton, Southampton 2: Child Health, Southampton University Hospitals NHS Trust, Southampton 3: Host Defence, Great Ormond Street Hospital NHS Trust, London, UK

Publication date: April 1, 2005

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