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The reduction of rhinitis symptoms by nasal filters during natural exposure to ragweed and grass pollen

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Abstract:

Background: 

Prototype nasal filters were developed to collect inhaled pollen. This study evaluated the efficacy of the filters for prevention of rhinitis symptoms during acute outdoor pollen exposure. Methods: 

A randomized double-blind design was used. Subjects (n = 46) with a history of autumn exacerbation of rhinitis and positive skin test to ragweed, Bermuda and/or Bahia grass wore either active or placebo nasal filters for 2 h in autumn in a park containing these species. Major and Total Symptoms scores were recorded at 0, 30, 60, 90 and 120 min. Results: 

Subjects wearing active nasal filters had significantly reduced scores, at all time-points compared with placebo group (all P < 0.05). Of 14 individual symptoms measured, seven were significantly reduced (number of sneezes, runny nose, itchy nose, sniffles, itchy throat; itchy eyes and watery eyes) and another three showed a trend towards lower severity. The nasal filters also enabled the resolution of existing symptoms. Maximal difference in symptoms was seen immediately after subjects had spent 20 min sitting beside a large patch of ragweed. Conclusion: 

This is the first clinical trial of a nasal filter. The results suggest it has potential for enhancing rhinitis management during acute allergen exposure.

Keywords: allergen avoidance; nose filter; prevention

Document Type: Short Communication

DOI: https://doi.org/10.1111/j.1398-9995.2005.00741.x

Affiliations: 1: Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, University of Sydney, New South Wales 2: Northern Rivers University Department of Rural Health, University of Sydney and Northern Rivers Area Health Service, Lismore New South Wales, Australia

Publication date: 2005-04-01

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