Identifying Specific Causes of Kidney Allograft Loss

Authors: El-Zoghby, Z. M.¹; Stegall, M. D.²; Lager, D. J.³; Kremers, W. K.⁴; Amer, H.¹; Gloor, J. M.¹; Cosio, F. G.

Source: American Journal of Transplantation, Volume 9, Number 3, March 2009 , pp. 527-535(9)

Buy & download fulltext article:

You have access to the full text article on a website external to ingentaconnect.

Please click here to view this article on Wiley Online Library.

You may be required to register and activate access on Wiley Online Library before you can obtain the full text. If you have any queries please visit Wiley Online Library

Abstract:

The causes of kidney allograft loss remain unclear. Herein we investigated these causes in 1317 conventional kidney recipients. The cause of graft loss was determined by reviewing clinical and histologic information the latter available in 98% of cases. During 50.3 ± 32.6 months of follow-up, 330 grafts were lost (25.0%), 138 (10.4%) due to death with function, 39 (2.9%) due to primary nonfunction and 153 (11.6%) due to graft failure censored for death. The latter group was subdivided by cause into: glomerular diseases (n = 56, 36.6%); fibrosis/atrophy (n = 47, 30.7%); medical/surgical conditions (n = 25, 16.3%); acute rejection (n = 18, 11.8%); and unclassifiable (n = 7, 4.6%). Glomerular pathologies leading to failure included recurrent disease (n = 23), transplant glomerulopathy (n = 23) and presumed nonrecurrent disease (n = 10). In cases with fibrosis/atrophy a specific cause(s) was identified in 81% and it was rarely attributable to calcineurin inhibitor (CNI) toxicity alone (n = 1, 0.7%). Contrary to current concepts, most cases of kidney graft loss have an identifiable cause that is not idiopathic fibrosis/atrophy or CNI toxicity. Glomerular pathologies cause the largest proportion of graft loss and alloinmunity remains the most common mechanism leading to failure. This study identifies targets for investigation and intervention that may result in improved kidney transplantation outcomes.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-6143.2008.02519.x

Affiliations: 1: Department of Internal Medicine, Division of Nephrology and Hypertension and William von Liebig Transplant Center 2: Department of Surgery and Transplant Center 3: Department of Pathology 4: Division of Biostatistics, Mayo Clinic, Rochester, MN

Publication date: 2009-03-01

Identifying Specific Causes of Kidney Allograft Loss

Buy & download fulltext article:

Tools

Key

Text size:

Useful pages