IngentaConnect Long-Term Outcome of Adult-to-Adult Living Donor Liver Transplant...

Authors: Uchida, Y.; Kasahara, M.¹; Egawa, H.¹; Takada, Y.²; Ogawa, K.²; Ogura, Y.²; Uryuhara, K.²; Morioka, D.²; Sakamoto, S.²; Inomata, Y.³; Kamiyama, Y.⁴; Tanaka, K.

Source: American Journal of Transplantation, Volume 6, Number 10, October 2006 , pp. 2443-2448(6)

Publisher: Blackwell Publishing

Abstract:

Our objective was to analyze problems in the perioperative management and long-term outcome of living donor liver transplantation (LDLT) for biliary atresia (BA). Many reports have described the effectiveness of liver transplantation (LT) for BA, particularly in pediatric cases, but little information is available regarding LT in adults (≥16 years old). Between June 1990 and December 2004, 464 patients with BA underwent LDLT at Kyoto University Hospital, of whom 47 (10.1%) were older than 16 years. In this study, we compared the outcomes between adult (≥16 years old) and pediatric (<16 years old) patients. The incidence of post-transplant intestinal perforation, intra-abdominal bleeding necessitating repeat laparotomy and biliary leakage was significantly higher (p < 0.0001, <0.001 and <0.001, respectively) in adults. Overall cumulative 1-, 5- and 10-year survival rates in pediatric patients were significantly higher (p < 0.005) than in adults. Two independent prognostic determinants of survival were identified: a MELD score over 20 and post-transplant complications requiring repeat laparotomy. Outcome of LDLT in adult BA patients was poorer than in pediatric patients. It seems likely that LT will be the radical treatment of choice for BA and that LDLT should be considered proactively at the earliest possible stage.

Keywords: Adult; biliary atresia; liver transplantation; living donor

Document Type: Research article

DOI: 10.1111/j.1600-6143.2006.01487.x

Affiliations: 1: Organ Transplant Unit, Department of Transplant Surgery, Kyoto University Hospital, Kyoto, Japan 2: Department of Transplantation and Immunology, Kyoto University Faculty of Medicine, Kyoto, Japan 3: Department of Pediatric and Transplant Surgery, Kumamoto University Hospital, Kumamoto, Japan 4: Department of Surgery, Kansai Medical University Hospital, Osaka, Japan

You have access to the full text article on a website external to Ingentaconnect.

Please click here to view this article on InterScience.

You may be required to register and activate access on InterScience before you can obtain the full text. If you have any queries please contact onlinehelp@oxon.blackwellpublishing.com

Long-Term Outcome of Adult-to-Adult Living Donor Liver Transplantation for Post-Kasai Biliary Atresia