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Free Content Alemtuzumab Induction and Prednisone-Free Maintenance Immunotherapy in Simultaneous Pancreas-Kidney Transplantation Comparison With Rabbit Antithymocyte Globulin Induction – Long-Term Results

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This study compared the effects of using two T-cell depleting antibodies, alemtuzumab (anti-CD 52, Campath-1H®) and rabbit antithymocyte globulin (Thymoglobulin®), as induction immunosuppression for recipients of simultaneous pancreas-kidney transplantation given a prednisone-free maintenance regimen. We used a single-center, nonrandomised, retrospective, sequential study design to evaluate the efficacy and safety of alemtuzumab (n = 50) or antithymocyte globulin (n = 38) induction in combination with a prednisone-free, tacrolimus/sirolimus-based immunosuppression protocol. Kaplan-Meier analyses of long-term patient and graft survivals and rejection rates were determined according to induction agent. Secondary endpoints included the quality of renal allograft function, incidence of infectious and malignant complications, and cost considerations. Overall long-term patient and graft survival rates did not significantly differ between patients treated with alemtuzumab and antithymocyte globulin. Rejection rates were also nearly equivalent at 1 and 2 years. Viral infectious complications were statistically significantly lower in the alemtuzumab group. The cost of alemtuzumab induction was lower than antithymocyte globulin. Alemtuzumab induction followed by steroid-free maintenance therapy with a tacrolimus/sirolimus-based immunosuppression regimen provided an effective, safe and cost-conscious approach to SPK transplantation.
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Keywords: Alemtuzumab; anti-thymocyte globulin; pancreas transplantation; steroid sparing

Document Type: Research Article

Affiliations: 1: Department of Surgery, Division of Transplantation 2: Department of Medicine, Division of Nephrology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA 3: Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, North Carolina, USA

Publication date: 01 February 2006

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