Peroxisome Proliferator-Activated Receptors: New Players in the Field of Reproduction

Authors: Toth, Bettina¹; Hornung, Daniela²; Scholz, Christoph³; Djalali, Schima²; Friese, Klaus; Jeschke, Udo³

Source: American Journal of Reproductive Immunology, Volume 58, Number 3, September 2007 , pp. 289-310(22)

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Abstract:

Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily. Synthetic ligands to one family member, PPARγ, are currently widely used as treatment for chronic diseases such as diabetes type II and other insulin resistances, e.g. as seen in polycystic ovary syndrome (PCOS). Moreover, novel approaches employing knock-out mice demonstrated that PPARγ seems to play a key role in placental and fetal development. This review describes recent insights into the role of PPARs in human reproduction with specific reference to infertility, placental maturation and fetal development as well as disturbed pregnancy. Further, we highlight the current knowledge on synthetic ligands to PPARγ used as a treatment in women with PCOS.

Keywords: Disturbed pregnancy; infertility; peroxisome proliferator-activated receptor; placenta; reproduction

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0897.2007.00514.x

Affiliations: 1: Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Großhadern, Munich, Germany; 2: Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany; 3: Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Maistrasse, Munich, Germany

Publication date: 2007-09-01