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Antichlamydial and Antisperm Antibodies in Patients with Chlamydial Infections

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Dimitrova D, Kalaydjiev S, Hristov L, Nikolov K, Boyadjiev T, Nakov L. Antichlamydial and antisperm antibodies in patients with chlamydial infections. AJRI 2004; 52:330–336 © Blackwell Munksgaard, 2004 Problem: 

Establishing the correlation between antichlamydial antibodies (AchAbs) and antisperm antibodies (ASA) in patients with chlamydial infections. Method of study: 

ASA were studied in sera from patients (142 with genital, 57 with ocular chlamydial infections) and control group (n = 100) by gelatin and tray agglutination test (TAT), sperm immobilization test (SIT) and ELISA. AchAbs were revealed by ELISA. Results: 

A significantly higher (P < 0.05) ASA incidence was noted in patients with genital infections as compared with controls and patients with ophthalmologic infection (P < 0.0001), but not between patients with ophthalmologic infection and controls (P > 0.05). A significant correlation was established between AchAbs and ASA for TAT (r = 0.8214, P = 0.0341), SIT (r = 0.797, P = 0.032) and ELISA (r = 0.8519, P = 0.0313) in patients with genital infections only. Conclusions: 

The genital Chlamydia infection may play a role in the induction of ASA. This is probably a result of the inflammatory process, but not of cross-reactivity between sperm and Chlamydia trachomatis antigens.
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Keywords: Cross-reactivity; genital chlamydial infections; human immune infertility; ocular chlamydial infections; serum antisperm antibodies; sperm antigens

Document Type: Research Article

Affiliations: 1: Department of Biology 2: Institute of Pediatrics 3: Department of Dermatology, Medical University of Sofia, Sofia 4: Faculty of Mathematics and Computer Science, Sofia University ‘‘St. Kliment Ohridski’’, Sofia, Bulgaria

Publication date: 01 November 2004

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