Thrombophilic Gene Mutations and Recurrent Spontaneous Abortion: Prothrombin Mutation Increases the Risk in the First Trimester

Authors: Pihusch R.; Hiller E.; Buchholz T.; Rogenhofer N.; Hasbargen U.; Thaler C.J.; Lohse P.; Rübsamen H.

Source: American Journal of Reproductive Immunology, Volume 46, Number 2, August 2001 , pp. 124-131(8)

Publisher: Blackwell Publishing

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

PROBLEM: Thrombophilic predisposition may be one of the underlying causes of recurrent spontaneous abortions (RSA). We studied the prevalence of five thrombophilic gene mutations in patients with RSA.

METHOD OF STUDY: 102 patients with two or more consecutive abortions and 128 women without miscarriage were analyzed for factor V Leiden mutation (FVL), prothrombin G20210A mutation (PTM), C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, glycoprotein IIIa (GPIIIa) C1565T polymorphism, and beta-fibrinogen G-455A polymorphism by polymerase chain reaction (PCR) techniques.

RESULTS: No differences in the prevalence of FVL, MTHFR T/T, GPIIIa and beta-fibrinogen polymorphism were detected. Heterozygous PTM occurred more often in patients with RSA. This effect was significant in a subgroup with abortions exclusively in the first trimester (6.7% vs. 0.8%, P=0.027, OR 8.5).

CONCLUSIONS: In contrast to the other mutations and polymorphisms, heterozygous PTM is more common in patients with abortions in the first trimester. This might reflect an influence of PTM on pathogenesis of early pregnancy loss.

Keywords: beta-Fibrinogen; factor V Leiden; genetic thrombophilia; GPIIIa; habitual abortion; MTHFR

Language: English

Document Type: Original article

DOI: 10.1034/j.1600-0897.2001.460202.x

Affiliations: Haemostaseology Research Laboratory, Department of Haematology and Oncology, Klinikum der Universität München-Großhadern, Munich, Germany Department of Obstetrics and Gynecology, Klinikum der Universität München-Großhadern, Munich, Germany Molecular Biology Laboratory, Department of Clinical Chemistry, Klinikum der Universität München-Großhadern, Munich, Germany : *

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.39 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A