Skip to main content

Neural correlates of self‐reflection in post‐traumatic stress disorder

Buy Article:

$43.00 plus tax (Refund Policy)

Bluhm RL, Frewen PA, Coupland NC, Densmore M, Schore AN, Lanius RA. Neural correlates of self‐reflection in post‐traumatic stress disorder.

Objective:  Disturbances in self‐referential processing (SRP) are increasingly recognized in post‐traumatic stress disorder (PTSD). In healthy adults, SRP tasks engage the medial prefrontal cortex (MPFC) and posterior cingulate cortex (PCC) brain regions that have shown altered function in PTSD. We hypothesized that individuals with PTSD would differ from controls in functional activation of the MPFC and PCC during SRP.

Method:  We compared neural activation in healthy controls (n = 15) and participants with PTSD (n = 20) during a SRP task, using fMRI at 4.0T.

Results:  Controls made faster responses to the self‐relevance of personal characteristics than to the accuracy of general facts, whereas response times did not differ between these conditions in PTSD. Controls also demonstrated greater MPFC (dorsal and ventral) and PCC response when considering the self‐relevance of personal characteristics in comparison with the accuracy of general facts. Individuals with PTSD demonstrated less MPFC response than did healthy controls for the contrast of self‐relevance of personal characteristics relative to general facts.

Conclusions:  These results implicate MPFC in SRP disturbances associated with PTSD. These findings are relevant to current proposals for including symptoms of negative self‐referential cognition and identity‐existential disturbance as diagnostically relevant to PTSD.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Document Type: Research Article

Affiliations: 1: Department of Philosophy and Religious Studies, Old Dominion University, Norfolk, VA, USA 2: Department of Chemistry, University of California at Los Angeles, Los Angeles, CA, USA, David Geffen School of Medicine 3: Departments of Psychiatry 4: Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada

Publication date: 01 March 2012

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more