An algorithm for the pharmacological treatment of depression

Authors: Spijker, J.; Nolen, W. A.

Source: Acta Psychiatrica Scandinavica, Volume 121, Number 3, March 2010 , pp. 180-189(10)

Publisher: Wiley-Blackwell

Buy & download fulltext article:


Price: $48.00 plus tax (Refund Policy)


Spijker J, Nolen WA. An algorithm for the pharmacological treatment of depression. Objective: 

Non-response to treatment with antidepressants (AD) is a clinical problem. Method: 

The algorithm for pharmacological treatment of the Dutch multidisciplinary guideline for depression is compared with four other algorithms. Results: 

The Dutch algorithm consists of five subsequent steps. Treatment is started with one out of many optional ADs (step 1); in case of non-response after 4–10 weeks, best evidence is for switching to another AD (step 2); next step is augmentation with lithium as the best option (step 3); the next step is a monoamine oxidase inhibitor (MAOI) (step 4); and finally electroconvulsive therapy (step 5). There are major differences with other algorithms regarding timing of augmentation step, best agents for augmentation and role of MAOI. Conclusion: 

Algorithms for AD treatment vary according to national and local preferences. Although the evidence for most of the treatment strategies is rather meagre, an AD algorithm appears to be an useful instrument in clinical practice.

Keywords: antidepressants; major depressive disorder; treatment algorithm

Document Type: Research Article


Affiliations: Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands

Publication date: March 1, 2010

Related content



Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page