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Preliminary results of a fine-grain analysis of mood swings and treatment modalities of bipolar I and II patients using the daily prospective life-chart-methodology

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Born C, Seitz N-N, Grunze H, Vieta E, Dittmann S, Seemüller F, Amann B. Preliminary results of a fine-grain analysis of mood swings and treatment modalities of bipolar I and II patients using the daily prospective life-chart-methodology. Objective: 

The study aimed to increase the knowledge about the detailed course differences between different forms of bipolar disorder. Method: 

Using the prospective life-chart-clinician version, we compared the fine-grain analysis of mood swings and treatment modalities of 18 bipolar II with 31 bipolar I patients. Results: 

During an observational period of a mean of 26 months we observed an increase of euthymic days, and a decrease of (sub)depressive and (hypo)manic days. Days in a (sub)depressed state were more frequent than days of (hypo)mania as well as days of subdepression or hypomania in comparison to days of full-blown depression or mania. Bipolar II patients showed an increase in hypomanic days receiving more frequently antidepressants. Bipolar I patients, with a decrease of manic days, were significantly taking more often mood stabilizers. Conclusion: 

Treatment in a specialized bipolar clinic improves the overall outcome, but bipolar II disorder seems to be still treated sub-optimally with a possible iatrogenic increase of hypomanic days.
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Keywords: affective states; antidepressants; bipolar disorder; long-term course; mood stabilizers

Document Type: Research Article

Affiliations: 1: Department of Psychiatry, Ludwig-Maximilian- University, Munich, Germany 2: Bipolar Disorders Program, Clinical Institute of Neuroscience, University Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain

Publication date: 01 December 2009

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