Authors: Born, C.¹; Seitz, N.-N.¹; Grunze, H.; Vieta, E.²; Dittmann, S.¹; Seemüller, F.¹; Amann, B.

Source: Acta Psychiatrica Scandinavica, Volume 120, Number 6, December 2009 , pp. 474-480(7)

Publisher: Wiley-Blackwell

Abstract:

Born C, Seitz N-N, Grunze H, Vieta E, Dittmann S, Seemüller F, Amann B. Preliminary results of a fine-grain analysis of mood swings and treatment modalities of bipolar I and II patients using the daily prospective life-chart-methodology. Objective: 

The study aimed to increase the knowledge about the detailed course differences between different forms of bipolar disorder. Method: 

Using the prospective life-chart-clinician version, we compared the fine-grain analysis of mood swings and treatment modalities of 18 bipolar II with 31 bipolar I patients. Results: 

During an observational period of a mean of 26 months we observed an increase of euthymic days, and a decrease of (sub)depressive and (hypo)manic days. Days in a (sub)depressed state were more frequent than days of (hypo)mania as well as days of subdepression or hypomania in comparison to days of full-blown depression or mania. Bipolar II patients showed an increase in hypomanic days receiving more frequently antidepressants. Bipolar I patients, with a decrease of manic days, were significantly taking more often mood stabilizers. Conclusion: 

Treatment in a specialized bipolar clinic improves the overall outcome, but bipolar II disorder seems to be still treated sub-optimally with a possible iatrogenic increase of hypomanic days.

Keywords: bipolar disorder; affective states; long-term course; antidepressants; mood stabilizers

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2009.01412.x

Affiliations: 1: Department of Psychiatry, Ludwig-Maximilian- University, Munich, Germany 2: Bipolar Disorders Program, Clinical Institute of Neuroscience, University Hospital Clinic, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain

Publication date: 2009-12-01

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