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Association between age of onset and symptom profiles of late-life depression

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Corruble E, Gorwood P, Falissard B. Association between age of onset and symptom profiles of late-life depression. Objective: 

The recognition of later late-onset (LLO) major depression (MD) is a matter of concern. Method: 

Cross-sectional study assessed MD with the MINI structured interview and the MADRS in a referred sample of 13 377 non-demented adult out-patients visiting their physicians. Among 6850 patients with a first episode of MD, 370 LLO (75 years of age and older) MD were compared with 814 late-onset (LO) (60–74 years old) MD and 5666 early-onset (EO) (18–59 years old) MD. Results: 

There are many similarities between the symptom patterns of EO, LO and LLO MDs. However, the symptom pattern of LLO MD includes more retardation/agitation, lassitude, reduced appetite and apparent sadness, and less sleep disturbances, guilt feelings, pessimism and inner tension than LO and EO MD. Conclusion: 

The differences in symptom profiles are very modest and between-group differences may not be meaningful on an individual level.

Keywords: age of onset; late-onset disorder; major depressive disorder

Document Type: Research Article


Affiliations: 1: Department of Psychiatry, Bicêtre University Hospital, INSERM U 669, Paris XI University, Assistance Publique–Hôpitaux de Paris, Le Kremlin Bicêtre 2: INSERM U675, Paris VII University (IFR02), Assistance Publique–Hôpitaux de Paris, Paris 3: Department of Biostatistics and Public Health, Paul Brousse Hospital, INSERM U669, Paris XI University, Assistance Publique–Hôpitaux de Paris, Villejuif, France

Publication date: November 1, 2008


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