IngentaConnect Loss of asymmetry in D2 receptors of putamen in unaffected family...

Authors: Lee, K. J.; Lee, J. S.¹; Kim, S. J.¹; Correll, C. U.²; Wee, H.³; Yoo, S. Y.⁴; Jeong, J. M.¹; Lee, D. S.¹; Lee, S. I.⁵; Kwon, J. S.

Source: Acta Psychiatrica Scandinavica, Volume 118, Number 3, September 2008 , pp. 200-208(9)

Publisher: Blackwell Publishing

Abstract:

Lee KJ, Lee JS, Kim SJ, Correll CU, Wee H, Yoo SY, Jeong JM, Lee DS, Lee SI, Kwon JS. Loss of asymmetry in D₂ receptors of putamen in unaffected family members at increased genetic risk for schizophrenia. Objective:

Dopamine dysregulation has been implicated in the pathophysiology of schizophrenia. The present study was performed to examine whether unaffected relatives at high genetic risk of schizophrenia have dopamine dysregulation in comparison with healthy controls. Method:

Eleven unaffected relatives from families with two or more first- or second-degree relatives with schizophrenia (n = 9) or with a monozygotic schizophrenic twin (n = 2) and 11 age- and sex-matched controls were examined using positron emission tomography (PET) with [¹¹C] raclopride. Subjects also underwent extensive neuropsychological testing. Results:

Subjects with high genetic risk showed a loss of asymmetry of D₂ receptors in the putamen in comparison with healthy controls. In addition, they showed significantly poorer performance on neuropsychological tests than controls. Conclusion:

Our results suggest that dopamine dysregulation and neuropsychological dysfunction may be present in subjects at high genetic risk of schizophrenia. However, further studies are required to confirm these findings.

Keywords: asymmetry; dopamine D2 receptor; genetic high-risk subjects; neurocognitive function; schizophrenia

Document Type: Research article

DOI: 10.1111/j.1600-0447.2008.01223.x

Affiliations: 1: Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul 2: Department of Psychiatry, The Zucker Hillside Hospital, North Shore - Long Island Jewish Health System, Glen Oaks, NY, USA 3: Neuroscience Institute, Seoul National University Medical Research Center, Seoul, South Korea 4: Seoul National University College of Medicine, Seoul 5: Chungbuk National University College of Medicine, Chungbuk, South Korea

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Loss of asymmetry in D2 receptors of putamen in unaffected family members at increased genetic risk for schizophrenia

Loss of asymmetry in D₂ receptors of putamen in unaffected family members at increased genetic risk for schizophrenia