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P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia

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Sánchez-Morla EM, García-Jiménez MA, Barabash A, Martínez-Vizcaíno V, Mena J, Cabranes-Díaz JA, Baca-Baldomero E, Santos JL. P50 sensory gating deficit is a common marker of vulnerability to bipolar disorder and schizophrenia. Objective: 

P50 gating in schizophrenia has contributed much to our understanding of the pathophysiology of the illness. We examined euthymic bipolar patients to determine if they also have a P50 gating deficit. Method: 

P50 gating was measured in 81 euthymic bipolar patients (50 with a lifetime history of psychotic symptoms), 92 stable schizophrenic patients, and 67 control subjects. Results: 

P50 gating was significantly lower in control subjects than in bipolar patients with a lifetime history of psychosis (P = 0.001) and schizophrenic patients (P = 0.0001). In all patient groups, the percentage of patients with P50 gating was higher than in the control group (χ2 = 30.596; P < 0.0001). There was no statistically significant correlation between P50 gating and other clinical variables. Conclusion: 

Our data suggest that P50 gating deficit is a neurobiological marker that is present in stable schizophrenic patients and euthymic bipolar patients.

Keywords: P50; bipolar disorder; psychotic symptoms; schizophrenia; sensory gating

Document Type: Research Article


Affiliations: 1: Neurophysiology Unit, Hospital Virgen de la Luz, Cuenca 2: Department of Psychiatry, Hospital Clínico San Carlos, Madrid 3: Department of Epidemiology, Health and Psychosocial Research Center, Universidad de Castilla-La Mancha, Cuenca 4: Department of Psychiatry, Universidad Autónoma de Madrid, Hospital Puerta de Hierro, Madrid 5: Department of Psychiatry, Hospital Virgen de la Luz, Cuenca, Spain

Publication date: April 1, 2008


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