If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder

$48.00 plus tax (Refund Policy)

Download / Buy Article:

Abstract:

Scherk H, Backens M, Schneider-Axmann T, Kemmer C, Usher J, Reith W, Falkai P, Gruber O. Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder. Objective: 

Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent. Method: 

N-acetyl-aspartate, choline (Cho), creatine (Cr) and myo-inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated. Results: 

Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen. Conclusion: 

We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.

Keywords: N-acetyl-aspartate; bipolar disorder; hippocampus; magnetic resonance spectroscopy; thalamus

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2007.01142.x

Affiliations: 1: Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Goettingen 2: Departments of Neuroradiology 3: Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany

Publication date: April 1, 2008

Related content

Tools

Favourites

Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
X
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more