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Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

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Abstract:

Iosifescu DV, Greenwald S, Devlin P, Perlis RH, Denninger JW, Alpert JE, Fava M. Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. Objective: 

We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: 

Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: 

During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: 

Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.

Keywords: major depressive disorder; quantitative electroencephalography; selective serotonin reuptake inhibitors; suicidal ideation

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2008.01156.x

Affiliations: 1: Depression Clinical and Research Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 2: Aspect Medical Systems, Inc., Norwood, MA, USA

Publication date: April 1, 2008

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