Skip to main content

Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder

Buy Article:

$43.00 plus tax (Refund Policy)

Iosifescu DV, Greenwald S, Devlin P, Perlis RH, Denninger JW, Alpert JE, Fava M. Pretreatment frontal EEG and changes in suicidal ideation during SSRI treatment in major depressive disorder. Objective: 

We investigated frontal quantitative EEG (QEEG) as predictor of changes in suicidal ideation (SI) during SSRI treatment in major depressive disorder (MDD). Method: 

Eighty-two subjects meeting DSM-IV criteria for MDD entered an 8-week, prospective, open-label treatment with flexible dose SSRIs and completed at least 4 weeks of treatment. We assessed MDD severity with the 17-item Hamilton Depression Rating Scale (HAM-D-17); change in SI was measured with HAM-D item no. 3. We recorded four-channel EEGs (F7-Fpz, F8-Fpz, A1-Fpz, A2-Fpz) before treatment. Results: 

During the first 4 weeks of treatment 9 (11%) subjects experienced worsening SI. Left-right asymmetry of combined theta + alpha power correlated significantly with change in SI from baseline, even when adjusting for changes in depression severity (HAM-D-17) and for the SSRI utilized. Conclusion: 

Frontal QEEG parameters before treatment may predict worsening SI during SSRI treatment in MDD.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: major depressive disorder; quantitative electroencephalography; selective serotonin reuptake inhibitors; suicidal ideation

Document Type: Research Article

Affiliations: 1: Depression Clinical and Research Program, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 2: Aspect Medical Systems, Inc., Norwood, MA, USA

Publication date: 2008-04-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more