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White matter abnormalities in drug-naïve patients with obsessive–compulsive disorder: a Diffusion Tensor Study before and after citalopram treatment

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Abstract:

Yoo SY, Jang JH, Shin Y-W, Kim DJ, Park H-J, Moon W-J, Chung EC, Lee J-M, Kim IY, Kim SI, Kwon JS. White matter abnormalities in drug-naïve patients with obsessive–compulsive disorder: a Diffusion Tensor Study before and after citalopram treatment. Objective: 

The aim was to investigate the white matter abnormalities of drug-naïve patients with obsessive–compulsive disorder (OCD) using diffusion tensor-imaging and the white matter changes in the patients after pharmacotherapy. Method: 

Thirteen drug-naïve OCD patients and 13 age- and sex-matched healthy comparison subjects were examined using diffusion tensor-imaging and structural magnetic resonance imaging. Measurements were made in OCD patients before and after 12 weeks of citalopram treatment. Results: 

Compared with controls, the drug-naïve OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, the internal capsule and white matter in the area superolateral to the right caudate. The increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared with controls. Conclusion: 

Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy.

Keywords: citalopram; diffusion magnetic resonance imaging; obsessive–compulsive disorder

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2007.01046.x

Affiliations: 1: Department of Psychiatry, Seoul National University College of Medicine, Seoul 2: Department of Biomedical Engineering, Hanyang University, Seoul, Korea 3: Department of Radiology, Yonsei University College of Medicine, Seoul 4: Department of Radiology, Kun Kuck University College of Medicine, Seoul 5: Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Publication date: September 1, 2007

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