The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery resolved?
Abstract:van Winkel R, Myin-Germeys I, De Hert M, Delespaul P, Peuskens J, van Os J. The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery resolved? Objective:
The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated. Method:
Associations between Intelligence Quotient (IQ) measures and functional outcome were assessed at the first hospitalization and after 10 years follow-up. Results:
Functional outcome was associated with estimated premorbid IQ and IQ at 10-year follow-up, but not with IQ assessed at first hospitalization. Conclusion:
The presence of a prospective as well as a cross-sectional relationship of the global cognitive measure IQ with 10-year functional outcome could be established. However, assessing associations between cognitive measures assessed at first hospitalization and subsequent functional outcome, can give inconclusive results due to non-uniform intellectual deterioration from premorbid level in the period preceding the first hospitalization.
Document Type: Research Article
Affiliations: 1: Department of Psychiatry and Neuropsychology (DRT10), European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands 2: University Psychiatric Center Catholic University Leuven, Leuvensesteenweg, Kortenberg, Belgium
Publication date: August 1, 2007