The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery resolved?

Authors: van Winkel, R.; Myin-Germeys, I.¹; De Hert, M.²; Delespaul, P.¹; Peuskens, J.²; van Os, J.

Source: Acta Psychiatrica Scandinavica, Volume 116, Number 2, August 2007 , pp. 119-124(6)

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Abstract:

van Winkel R, Myin-Germeys I, De Hert M, Delespaul P, Peuskens J, van Os J. The association between cognition and functional outcome in first-episode patients with schizophrenia: mystery resolved? Objective:

The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated. Method:

Associations between Intelligence Quotient (IQ) measures and functional outcome were assessed at the first hospitalization and after 10 years follow-up. Results:

Functional outcome was associated with estimated premorbid IQ and IQ at 10-year follow-up, but not with IQ assessed at first hospitalization. Conclusion:

The presence of a prospective as well as a cross-sectional relationship of the global cognitive measure IQ with 10-year functional outcome could be established. However, assessing associations between cognitive measures assessed at first hospitalization and subsequent functional outcome, can give inconclusive results due to non-uniform intellectual deterioration from premorbid level in the period preceding the first hospitalization.

Keywords: Intelligence; schizophrenia; outcomes research

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2007.01014.x

Affiliations: 1: Department of Psychiatry and Neuropsychology (DRT10), European Graduate School of Neuroscience, Maastricht University, Maastricht, The Netherlands 2: University Psychiatric Center Catholic University Leuven, Leuvensesteenweg, Kortenberg, Belgium

Publication date: 2007-08-01