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C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients

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Hoenicka J, Aragüés M, Rodríguez-Jiménez R, Ponce G, Martínez I, Rubio G, Jiménez-Arriero MA, Palomo T, Psychosis and Addictions Research Group (PARG). C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients. Objective: 

The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population. Method: 

We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age-matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products. Results: 

The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over-represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2–3.4). Conclusion: 

The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.

Keywords: dopamine; dopamine-D2 receptor; genetic polymorphism; schizophrenia

Document Type: Research Article


Affiliations: 1: Psychiatry Service, Dual Diagnosis Unit, ‘12 de Octubre’ University Hospital 2: Retiro Mental Health Service, Gregorio Marañón University Hospital, Madrid, Spain

Publication date: December 1, 2006


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