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The persistence of depression score

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Spijker J, de Graaf R, Ormel J, Nolen WA, Grobbee DE, Burger H. The Persistence of Depression Score. Objective: 

To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research. Method: 

Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R. These subjects were recruited from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), using the Composite International Diagnostic Interview. Determinants for persistence were transformed into a practical risk score using proportional hazards models and bootstrapping techniques. Results: 

The risk of MDE persistence after 12 months was 23%. The score comprised measures of physical illness, social support, depression severity and recurrency, and duration of previous episodes. With increasing categories of these measures, the predicted risks increased from 7 to 40%. Conclusion: 

We constructed the Persistence of Depression Score (PDS) showing reasonable performance. The PDS could be of importance in clinical practice to support treatment decisions.

Keywords: depression; general population; prognosis; risk assessment

Document Type: Research Article


Affiliations: 1: Netherlands Institute of Mental Health and Addiction, Utrecht, The Netherlands 2: Department of Psychiatry, University Medical Centre, Groningen, The Netherlands 3: Julius Centre for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands

Publication date: 2006-12-01

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