MRI volumetric and 31P MRS metabolic correlates of caudate nucleus in antipsychotic-naïve schizophrenia
To examine the volumetric and metabolic correlates of caudate nucleus in antipsychotic-naïve schizophrenia patients in comparison with healthy controls. Method:
Twelve antipsychotic-naïve schizophrenia patients and 13 healthy controls underwent 31P magnetic resonance spectroscopy of basal ganglia. Magnetic resonance imaging volume of caudate nuclei was measured usingscion imagesoftware. Results:
Patients had significantly smaller caudate volume than healthy controls. Phosphocreatine (PCr)/total phosphorous and PCr/total adenosine tri-phosphate ratios of both caudate nuclei were significantly lower in patients than controls. Significant negative correlation was found between the left caudate volume and left PCr/total phosphorus ratio in the patients. Age at onset of psychosis had i) significant negative correlation with right and left caudate volumes and ii) significant positive correlation with left PCr/total phosphorus ratio. Conclusion:
The metabolic and volumetric abnormalities of caudate nucleus in antipsychotic-naïve schizophrenia patients support neurodevelopmental etiopathogenesis.
Document Type: Research Article
Affiliations: 1: Department of Neuroimaging and Interventional Radiology 2: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India 3: Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
Publication date: 2006-11-01