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MRI volumetric and 31P MRS metabolic correlates of caudate nucleus in antipsychotic-naïve schizophrenia

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Abstract:

Jayakumar PN, Venkatasubramanian G, Keshavan MS, Srinivas JS, Gangadhar BN. MRI volumetric and 31P MRS metabolic correlates of caudate nucleus in antipsychotic-naïve schizophrenia. Objective: 

To examine the volumetric and metabolic correlates of caudate nucleus in antipsychotic-naïve schizophrenia patients in comparison with healthy controls. Method: 

Twelve antipsychotic-naïve schizophrenia patients and 13 healthy controls underwent 31P magnetic resonance spectroscopy of basal ganglia. Magnetic resonance imaging volume of caudate nuclei was measured usingscion imagesoftware. Results: 

Patients had significantly smaller caudate volume than healthy controls. Phosphocreatine (PCr)/total phosphorous and PCr/total adenosine tri-phosphate ratios of both caudate nuclei were significantly lower in patients than controls. Significant negative correlation was found between the left caudate volume and left PCr/total phosphorus ratio in the patients. Age at onset of psychosis had i) significant negative correlation with right and left caudate volumes and ii) significant positive correlation with left PCr/total phosphorus ratio. Conclusion: 

The metabolic and volumetric abnormalities of caudate nucleus in antipsychotic-naïve schizophrenia patients support neurodevelopmental etiopathogenesis.

Keywords: 31P magnetic resonance spectroscopy; caudate; magnetic resonance imaging; schizophrenia

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2006.00836.x

Affiliations: 1: Department of Neuroimaging and Interventional Radiology 2: Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India 3: Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA

Publication date: November 1, 2006

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