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Medication decisions and clinical outcomes in the Canadian National Outcomes Measurement Study in Schizophrenia

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Williams R, Kopala L, Malla A, Smith G, Love L, Balshaw R. Medication decisions and clinical outcomes in the Canadian National Outcomes Measurement Study in Schizophrenia.

Acta Psychiatr Scand 2006: 113 (Suppl. 430): 12–21. © 2006 Blackwell Munksgaard. Objective: 

To evaluate over a 2-year period, patients from academic/non-academic centres, from each region of Canada, to determine whether location or other variables such as medication type, gender or income was associated with outcome as defined by non-hospitalization and persistence on original treatment. Method: 

A total of 448 patients were recruited from academic and non-academic centres across all provinces of Canada and followed up for 2 years. Results: 

Patients from British Columbia had significantly lower rates of hospitalization than patients from other provinces. Male patients showed greater symptomatic improvement at 2 years from initial assessment compared to females. Patients on clozapine, risperidone and olanzapine were least likely to be hospitalized. Conclusion: 

There were some regional differences noted in both utilization of types of antipsychotic medications and hospitalization rates. In this sample of stable out-patients over 70% who started on monotherapy with clozapine, risperidone, olanzapine and quetiapine remained on the same medication over the 2-year study period.

Keywords: Canada; hospitalization; outcome assessment; schizophrenia

Document Type: Research Article


Affiliations: 1: Department of Psychiatry, University of British Columbia, Vancouver, BC 2: Department of Psychiatry, McGill University, Montreal, QC 3: Syreon Corporation, Vancouver, BC, Canada

Publication date: May 1, 2006


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