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Altered neural circuit for working memory before and after symptom provocation in patients with obsessive–compulsive disorder

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Shin Y-W, Kwon JS, Kim J-J, Kang D-H, Youn T, Kang KW, Kang E, Lee DS, Lee MC. Altered neural circuit for working memory before and after symptom provocation in patients with obsessive–compulsive disorder.

Acta Psychiatr Scand 2005: 1–10. © 2005 Blackwell Munksgaard. Objective: 

The authors compared the neural circuits recruited for working memory (WM) in obsessive–compulsive disorder (OCD) patients both at a neutral state and at a symptom provoked state. Method: 

Twelve OCD patients, and 12 age-, and sex-matched healthy subjects underwent [15O]H2O positron emission tomography (PET) scanning, while performing WM task. In the patients, the tasks were performed both in the neutral and in the symptom provoked states. Results: 

In the OCD patients, the right caudate and the right superior parietal cortex (rSPC) displayed activations for WM at the neutral state, while the right cingulate cortex and rSPC displayed activations for WM at the symptom provoked state. Path analysis revealed that the activity of the caudate and orbitofrontal cortex was altered according to the interaction between WM and symptom provocation. Conclusion: 

The interaction between symptom provocation and WM occurring in the fronto-striatal system may hold the key to the neurobiology of OCD.
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Keywords: obsessive–compulsive disorder; path analysis; response inhibition; symptom provocation; working memory

Document Type: Research Article

Affiliations: 1: Department of Psychiatry, Seoul National University College of Medicine and Institute for Neuroscience, SNU-MRC 2: Department of Psychiatry, Yonsei University College of Medicine 3: Department of Psychology, Kangwon National University, Chuncheon, South Korea 4: Department of Nuclear Medicine and BK21 Human Life Sciences, Seoul National University College of Medicine

Publication date: 2006-05-01

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