@article {Lee:January 2006:0001-690X:64, author = "Lee, J.-S.", author = "Yoo, S.-S.", author = "Cho, S.-Y.", author = "Ock, S.-M.", author = "Lim, M.-K.", author = "Panych, L. P.", title = "Abnormal thalamic volume in treatment-naive boys with Tourette syndrome", journal = "Acta Psychiatrica Scandinavica", volume = "113", year = "January 2006", abstract = "Lee J-S, Yoo S-S, Cho S-Y, Ock S-M, Lim M-K, Panych LP. Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome. <br />Acta Psychiatr Scand 2005: 1–4. © 2005 Blackwell Munksgaard. Objective:
Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI). Method: Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. Results: Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. Conclusion: Our findings provide new evidence of abnormal thalamic volume in pediatric TS.", pages = "64-67(4)", url = "http://www.ingentaconnect.com/content/mksg/acp/2006/00000113/00000001/art00011" doi = "doi:10.1111/j.1600-0447.2005.00666.x" }