Authors: Lee, J.-S.¹; Yoo, S.-S.²; Cho, S.-Y.¹; Ock, S.-M.³; Lim, M.-K.⁴; Panych, L. P.²

Source: Acta Psychiatrica Scandinavica, Volume 113, Number 1, January 2006 , pp. 64-67(4)

Publisher: Wiley-Blackwell

Abstract:

Lee J-S, Yoo S-S, Cho S-Y, Ock S-M, Lim M-K, Panych LP. Abnormal thalamic volume in treatment-naïve boys with Tourette syndrome. <br />Acta Psychiatr Scand 2005: 1–4. © 2005 Blackwell Munksgaard. Objective: 

Thalamic abnormality has been implicated in the pathophysiology of Tourette's syndrome (TS). We examined the presence of aberrant thalamic volume from the treatment-naïve boys with TS using magnetic resonance imaging (MRI). Method: 

Volumetric MRI was performed on 18 treatment-naïve boys with TS, aged 7–14 years, and 16 healthy comparison subjects. The anatomical boundaries were then manually parcellated to measure the thalamic volume. Results: 

Tourette's syndrome subjects had a significantly larger left thalamus in comparison with those of healthy subjects. On the contrary, no group difference was observed from the right thalamic volume. TS subjects also showed a significant reduction in rightward asymmetry in thalamic volume compared with the healthy subjects. Conclusion: 

Our findings provide new evidence of abnormal thalamic volume in pediatric TS.

Keywords: Tourette syndrome; thalamus; magnetic resonance imaging

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2005.00666.x

Affiliations: 1: Department of Psychiatry, Inha University Hospital and College of Medicine, Incheon, South Korea 2: Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA 3: Department of Family Medicine, Catholic University Medical College, Uijongbu 4: Department of Radiology, Inha University Hospital and College of Medicine, Incheon, South Korea

Publication date: 2006-01-01

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