No association between the −399 C>T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

Authors: Lindberg, C.; Koefoed, P.; Hansen, E. S.¹; Bolwig, T. G.¹; Rehfeld, J. F.²; Mellerup, E.³; Jørgensen, O. S.³; Kessing, L. V.¹; Werge, T.⁴; Haugbøl, S.⁵; Wang, A. G.⁶; Woldbye, D. P. D.³

Source: Acta Psychiatrica Scandinavica, Volume 113, Number 1, January 2006 , pp. 54-58(5)

Publisher: Blackwell Publishing

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Abstract:

Lindberg C, Koefoed P, Hansen ES, Bolwig TG, Rehfeld JF, Mellerup E, Jørgensen OS, Kessing LV, Werge T, Haugbøl S, Wang AG, Woldbye DPD. No association between the –399 C>T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population. <br />Acta Psychiatr Scand 2005: 1–5. © 2005 Blackwell Munksgaard. Objective:

A polymorphism in the promoter region of the NPY gene at position −399 C>T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population. Method:

We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716). Results:

We detected the polymorphism −399 C>T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups. Conclusion:

The lack of association between the −399 C>T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population.

Keywords: case–control studies; neuropeptide Y; promoter regions (genetics); single-nucleotide polymorphism; schizophrenia; unipolar depression; panic disorder

Document Type: Research article

DOI: 10.1111/j.1600-0447.2005.00648.x

Affiliations: 1: Psychiatry, Rigshospitalet University Hospital, Copenhagen 2: Departments of Clinical Biochemistry 3: Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen & Rigshospitalet University Hospital, Copenhagen 4: Research Institute of Biological Psychiatry, H:S Sct. Hans Hospital, Roskilde 5: Neurobiology Research Unit 9201, Rigshospitalet University Hospital, Copenhagen 6: University Department of Psychiatry, H:S Amager Hospital, Copenhagen, Denmark

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