If you are experiencing problems downloading PDF or HTML fulltext, our helpdesk recommend clearing your browser cache and trying again. If you need help in clearing your cache, please click here . Still need help? Email help@ingentaconnect.com

Neuropharmacological basis of combining antidepressants

$48.00 plus tax (Refund Policy)

Download / Buy Article:


de la Gándara J, Rojo JE, Ros S, Agüera L, de Pedro JM. Neuropharmacological basis of combining antidepressants.

Acta Psychiatr Scand 2005: 112 (Suppl. 428): 11–13. © 2005 Blackwell Munksgaard. Objective: 

To review the neuropharmacological basis of antidepressant combination therapy. Method: 

Literature searches and other relevant material were obtained and reviewed. Results: 

The overall clinical aim of combining antidepressants is to increase the efficacy whilst minimizing the side effects. Although such prescriptions are frequently based on the previous experience and knowledge, a sound neuropharmacological basis to support these combinations is desirable. When combining antidepressants, it is important to combine mechanisms of action, rather than simply one drug with another, and to aim for synergistic effects. The possibilities of combining mechanisms of action should also be exploited to the full if necessary, and the potential exists for combining two independent actions that have synergistic effects on the serotonergic, noradrenergic and even the dopaminergic systems. Conclusion: 

Unfortunately, there are still, as yet, insufficient data to categorically justify choosing one or other combination based only on the neuropharmacological evidence.

Keywords: antidepressants; depression; drug combinations; neuropharmacology; noradrenergic; serotonergic

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1600-0447.2005.00675.x

Affiliations: 1: Hospital General Yagüe, Burgos 2: Hospital Universitàri de Bellvitge, L'Hospitalet de Llobregat 3: Hospital del Mar, Barcelona 4: Hospital Universitario 12 de Octubre, Madrid 5: Medical Department, Organon Spain SA, Barcelona, Spain

Publication date: November 1, 2005

Related content



Share Content

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more