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Atypical neuroleptic malignant syndrome caused by olanzapine

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Nielsen J, Bruhn AM. Atypical neuroleptic malignant syndrome caused by olanzapine.

Acta Psychiatr Scand 2005: 1–3. © 2005 Blackwell Munksgaard. Objective: 

Neuroleptic malignant syndrome (NMS) is a rare syndrome with four main symptoms: rigidity, hyperthermia, altered mental status and autonomic instability. We report a patient with an atypical manifestation of NMS. Method: 

A single case was reported. Results: 

A patient with pneumonia developed delirium and was treated with olanzapine and developed a NMS with fluctuating hyperthermia and autonomic instability during a month. Only slight rigidity was present. Creatine kinase was not elevated. The patient was severely agitated and manic. After discontinuation of olanzapine the patient showed no psychopathology or hyperthermia. Conclusion: 

NMS should be considered when patients treated with antipsychotics develop one or more symptoms of NMS.
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Keywords: NMS; neuroleptic malignant syndrome; olanzapine

Document Type: Research Article

Affiliations: Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg

Publication date: 2005-09-01

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