Atypical neuroleptic malignant syndrome caused by olanzapine
Abstract:Nielsen J, Bruhn AM. Atypical neuroleptic malignant syndrome caused by olanzapine.
Acta Psychiatr Scand 2005: 1–3. © 2005 Blackwell Munksgaard. Objective:
Neuroleptic malignant syndrome (NMS) is a rare syndrome with four main symptoms: rigidity, hyperthermia, altered mental status and autonomic instability. We report a patient with an atypical manifestation of NMS. Method:
A single case was reported. Results:
A patient with pneumonia developed delirium and was treated with olanzapine and developed a NMS with fluctuating hyperthermia and autonomic instability during a month. Only slight rigidity was present. Creatine kinase was not elevated. The patient was severely agitated and manic. After discontinuation of olanzapine the patient showed no psychopathology or hyperthermia. Conclusion:
NMS should be considered when patients treated with antipsychotics develop one or more symptoms of NMS.