Depression and chronic obstructive pulmonary disease (COPD). Impact on survival
Authors: Stage, K. B.1; Middelboe, T.2; Pisinger, C.3
Source: Acta Psychiatrica Scandinavica, Volume 111, Number 4, April 2005 , pp. 320-323(4)
Publisher: Wiley-Blackwell
Abstract:
Stage KB, Middelboe T, Pisinger C. Depression and chronic obstructive pulmonary disease (COPD). Impact on survival. Acta Psychiatr Scand 2005: 14. ©Blackwell Munksgaard 2005. Objective: To determine if the presence of depression in patients suffering from chronic obstructive pulmonary disease (COPD) would have an independent impact on mortality. Method: Prospective evaluation of the impact of depression according to the ICD-10 criteria for depression. Cox proportional hazards regression was used to evaluate the independent impact of depression after controlling for significant univariate clinical predictors in the data set. Consenting out-patients (n = 49) who meet the criteria for COPD between September 1997 and September 1998. There were no age limits (range: 5390 years). The sample was 67% female. Survival status at follow-up after a mean of 803 days was measured. Results: At follow-up, 16 patients had died. Depression significantly reduced the mortality risk at follow-up (hazard ratio, 0.30; 95% confidence interval, 0.100.93; P = 0.037). The impact of depression remained after control for forced expiratory volume during the first second (FEV1), the only multivariate significant predictor of mortality in the data set (hazard ratio, 0.27; 95% confidence interval, 0.090.84; P = 0.024). Conclusion: Depression in out-patients suffering from COPD appears to be an independent protector for mortality. Additional studies in larger samples are needed to replicate this finding and to determine possible underlying pathogenetic mechanisms.Keywords: depression; chronic obstructive pulmonary disease; survival
Document Type: Research article
DOI: http://dx.doi.org/10.1111/j.1600-0447.2004.00497.x
Affiliations: 1: Department of Psychiatry, Odense University Hospital, Odense C 2: Department of Psychiatry, Gentofte University Hospital, Hellerup 3: Center of Preventive Medicine, Glostrup University Hospital, Glostrup, Denmark
Publication date: 2005-04-01
- In this: publication
- By this: publisher
- In this Subject: Neurology & Psychiatry
- By this author: Stage, K. B. ; Middelboe, T. ; Pisinger, C.

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