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Hallucinatory experiences and onset of psychotic disorder: evidence that the risk is mediated by delusion formation

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Krabbendam L, Myin-Germeys I, Hanssen M, Bijl RV, de Graaf R, Vollebergh W, Bak M, van Os J. Hallucinatory experiences and onset of psychotic disorder: evidence that the risk is mediated by delusion formation.

Acta Psychiatr Scand 2004: 110: 264–272. © Blackwell Munksgaard 2004. Objective: 

To examine the hypothesis that the risk for onset of psychotic disorder in individuals with self-reported hallucinatory experiences (HE) would be higher in those who developed delusional ideation (DE) than in those who did not. Method: 

A population sample of 4673 individuals were interviewed with the Composite International Diagnostic Interview at baseline and 1 and 3 years later. At year 3, clinical re-interview took place to identify onset of psychotic disorder. Results: 

Given the presence of HEs at baseline, the increase in risk of having the psychosis outcome at year 3 was much higher in those with DE at year 1 than in those without DE (risk difference between individuals with and without DE: 18.72%, 95% CI: 2.22–35.23, 2 = 4.94, df = 1, P = 0.026). Conclusion: 

The results are in line with current psychological theories stating that clinical outcome of psychosis-like experiences is related to the development of secondary beliefs and appraisals.

Keywords: cognition; models; psychological; psychotic disorders; risk factors

Document Type: Research Article


Affiliations: 1: Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands 2: The Netherlands Institute of Mental Health and Addiction, Trimbos-Institute, Utrecht, The Netherlands

Publication date: October 1, 2004


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