No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis
Abstract:Robertson E, Jones I, Middle F, Moray J, Craddock N. No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis.
Acta Psychiatr Scand 2003: 108: 387–391. © Blackwell Munksgaard 2003. Objective:
To examine whether variation at two common polymorphisms, T102C and −1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis. Method:
A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group).
The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth. Results:
No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism. Conclusion:
The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.