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Postmaturity in a genetic subtype of schizophrenia

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Chow EWC, Husted J, Weksberg R, Bassett AS. Postmaturity in a genetic subtype of schizophrenia.

Acta Psychiatr Scand 2003: 108: 260–268. © Blackwell Munksgaard 2003. Objective:

To determine whether postmaturity (gestation > 41 weeks), small for gestational age (SGA), and other pregnancy and birth complications that may elevate risk for neurodevelopmental disorders, are associated with elevated risk for schizophrenia in 22q11 Deletion Syndrome (22qDS), a genetic subtype of schizophrenia. Method:

Antepartum and intrapartum features were examined in 20 adults with 22qDS-schizophrenia and three comparison groups: newborn encephalopathy (n = 164) and healthy newborn controls (n = 400) from Badawi et al.'s (Br Med J 1998, 317: 1549) study, and 16 non-psychotic 22qDS adults (22qDS-NP). Results:

Postmaturity (OR 13.0, 95% CI 3.95, 42.77; P < 0.001) and SGA (OR 3.59, 95% CI 1.23, 10.5; P = 0.03) were more prevalent in 22qDS-SZ than controls. Postmaturity was non-significantly more prevalent in 22qDS-SZ than in newborn encephalopathy (P = 0.06) or 22qDS-NP (P = 0.2). SGA showed similar rates in the two 22qDS groups and newborn encephalopathy, but was more prevalent in 22qDS-NP than controls (P = 0.05). Conclusion:

The results suggest that postmaturity may be associated with expression of schizophrenia in a 22qDS subtype of schizophrenia. SGA may be a non-specific marker of neurodevelopmental disturbance.

Keywords: DiGeorge syndrome; chromosome disorders; pregnancy complications; prolonged pregnancy; schizophrenia

Document Type: Research Article


Affiliations: 1: Department of Health Studies and Gerontology, University of Waterloo, Waterloo, 2: Departments of Pediatrics and Genetics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Publication date: October 1, 2003

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