Comorbid personality disorder predicts suicide after major depression: a 10-year follow-up
Abstract:Hansen PEB, Wang AG, Stage KB, Kragh-Sorensen P, The Danish University Antidepressant Group. Comorbid personality disorder predicts suicide after major depression. a 10-year follow-up.
Acta Psychiatr Scand 2003: 107: 436–440. © Blackwell Munksgaard 2003. Objective:
To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. Method:
A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics. Results:
The suicide rate for non-melancholic depressed patients was significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15–10.10)]. Conclusion:
The study indicates that the non-melancholic aspect of depression, and especially comorbid personality disorder, is associated with an increased suicidal vulnerability.
Document Type: Research Article
Affiliations: 1: Department of Psychiatry, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Aarhus, Denmark, 2: Department of Psychiatry, H:S Amager Hospital, Copenhagen Universuty Hospital, Copenhagen, Denmark and 3: Department of Psychiatry, Odense University Hospital, Odense, Denmark
Publication date: June 1, 2003