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Comorbid personality disorder predicts suicide after major depression: a 10-year follow-up

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Hansen PEB, Wang AG, Stage KB, Kragh-Sorensen P, The Danish University Antidepressant Group. Comorbid personality disorder predicts suicide after major depression. a 10-year follow-up.

Acta Psychiatr Scand 2003: 107: 436–440. © Blackwell Munksgaard 2003. Objective: 

To identify psychopathological predictors for suicide in a population of major depressed Diagnostic Statistical Manual-III (DSM-III) in-patients. Method: 

A total of 210 previous participants in multicentre antidepressant drug trials, carried out in a randomized double-blind design, were followed prospectively through a maximum of 10 years. Patients with a drug or alcohol abuse were excluded. The association between suicide and the pretreatment psychopathological profile was analysed using survival statistics. Results: 

The suicide rate for non-melancholic depressed patients was significantly higher than for melancholic depressed patients. Comorbid personality disorder was independently associated with an increased suicide rate [relative hazard 3.41(CI: 1.15–10.10)]. Conclusion: 

The study indicates that the non-melancholic aspect of depression, and especially comorbid personality disorder, is associated with an increased suicidal vulnerability.

Keywords: Melancholia; Newcastle 1965 scale; affective disorders; comorbidity; major depression; personality disorder; suicide

Document Type: Research Article


Affiliations: 1: Department of Psychiatry, Psychiatric Hospital in Aarhus, Aarhus University Hospital, Aarhus, Denmark, 2: Department of Psychiatry, H:S Amager Hospital, Copenhagen Universuty Hospital, Copenhagen, Denmark and 3: Department of Psychiatry, Odense University Hospital, Odense, Denmark

Publication date: June 1, 2003


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