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Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study

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Artero S, Tierney MC, Touchon J, Ritchie K. Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study.

Acta Psychiatr Scand 2003: 107: 390–393. © Blackwell Munksgaard 2003. Objective:

The purpose of this investigation was to replicate the statistical approach used in a previous investigation (Toronto study) within a French population to determine the best predictive model for Alzheimer's disease (AD). Method:

Data from neuropsychological tests from two prospective studies were entered into a regression model. Results:

Replication of the statistical approach in the Montpellier sample produced a three-test model with a specificity of 99% and sensitivity of 73%. This model consisted of a delayed auditory verbal recall test, a construction test, a category fluency test and provides probability estimates for the transition to dementia in individual cases. Conclusion:

The models derived from these two longitudinal studies provide an empirical basis for the selection of tests for the definition of mild cognitive impairment of the Alzheimer type (MCI-A). The small set of tests derived are suitable for use in general practice.

Keywords: Alzheimer's disease; cognition; mild cognitive impairment

Document Type: Research Article


Affiliations: 1: French National Institute of Health and Medical Research, INSERM EMI 9930 Epidemiology of Nervous System Pathologies, Montpellier, France and 2: Geriatric Research, Sunnybrook and Women's College Health Sciences Centre, Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada

Publication date: May 1, 2003


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