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Long-term effectiveness of risperidone and olanzapine in resistant or intolerant schizophrenic patients. A mirror study

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Søholm B, Lublin H. Long-term effectiveness of risperidone and olanzapine in resistant or intolerant schizophrenic patients. A mirror study.

Acta Psychiatr Scand 2003: 107: 344–350. © Blackwell Munksgaard 2003. Objective: 

To evaluate the long-term effectiveness of the second generation antipsychotics, risperidone and olanzapine on hospitalization, clinical response, and adherence to therapy after switching from conventional antipsychotics or clozapine in a naturalistic setting of schizophrenic patients. Method: 

Data were registered for periods of identical duration before and after switching. Results: 

Fifty-seven patients were included. Mean study period was 3.1 ± 0.2 years. Mean number of in-patient days after switching declined by 78% of the level before switching (P=0.0002). There was no significant differences in ratio responders/non-responders between the subgroups. The number of patients with extrapyramidal symptoms (EPS) was significantly reduced after switching. However, intolerable weight gain led to a lack of adherence to therapy in 18% of the olanzapine-treated patients. Conclusion: 

Long-term treatment with the second generation antipsychotics, risperidone and olanzapine significantly improved the clinical outcome. However, weight gain may be a significant reason for discontinuation of treatment and reducing the long-term adherence to therapy.
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Keywords: compliance; olanzapine; risperidone; schizophrenia; weight gain

Document Type: Research Article

Affiliations: Psychiatric Department O, Psychiatric Clinic, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Publication date: 01 May 2003

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