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Agranulocytosis and granulocytopenia associated with quetiapine

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Objective: Quetiapine is a recently introduced atypical antipsychotic. Although adverse effects are mainly mild, more serious infrequent adverse effects including leucopenia are mentioned.

Method: We describe three case-reports concerning haematological adverse effects of quetiapine.

Results: Quetiapine was associated with leucopenia in two patients and clinically apparent agranulocytosis in one patient.

Conclusion: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine. Further post-marketing surveys are required.

Keywords: agranulocytosis; antipsychotic agents; clozapine; dibenzothiazepines; leucopenia; quetiapine

Document Type: Research Article

Affiliations: 1: MFO Psychiatrie AMC/de Meren, Academic Medical Centre, Amsterdam, The Netherlands and 2: Stichting Lareb (Netherlands Pharmacovigilance Foundation), ‘s-Hertogenbosch, The Netherlands

Publication date: October 1, 2001

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