Skip to main content

Moclobemide vs. imipramine in bipolar depression: a multicentre double-blind clinical trial

Buy Article:

The full text article is temporarily unavailable.

We apologise for the inconvenience. Please try again later.


Objective: To determine the relative efficacy, tolerability and risk of precipitating mania of moclobemide and imipramine in the treatment of bipolar depression.

Method: A randomized, double-blind, parallel group, multicentre study of moclobemide (MCB) (450–750 mg daily) and imipramine (IMI) (150–250 mg daily) in 21 centres in nine countries; 156 patients (65 males, 91 females) aged 18–65 with bipolar depression (17-item Hamilton Depression Rating Scale (HAMD) score χ16) participated. Clinical status was assessed using standardized rating scales before treatment and at 1,2,3,4,6 and 8 weeks. The data were analysed on an intention to treat basis with the last observation carried forward.

Results: In the MCB group, the mean HAMD fell from 23.0 to 13.1, in the IMI group it fell from 22.5 to 9.5; the mean score on the Montgomery–Asberg Depression Rating Scale (MADRS) fell from 29.5 to 16.3 on MCB and from 29.2 to 11.6 on IMI. There were no statistically significant differences between the two groups on any efficacy measures. Anticholinergic side-effects were three times more common with IMI than MCB and weight gain was also greater on IMI. Two patients (3.7%) on MCB and six patients (11%) on IMI were withdrawn because of manic symptoms, with manic symptoms occurring earlier on IMI, although these differences did not reach statistical significance.

Conclusion: No differences in efficacy were detected between MCB and IMI in the treatment of bipolar depression. The data suggests that MCB is less likely than IMI to precipitate mania.

Keywords: bipolar disorder; depression; imipramine; mania; moclobemide

Document Type: Original Article

Affiliations: Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand

Publication date: August 1, 2001


Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
ingentaconnect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more
Real Time Web Analytics