Symptomatic recovery and social functioning in major depression
Method: Psychiatric out-patients or in-patients aged 18 years or over, diagnosed with unipolar major depressive disorder according to DSM-IV, and who had received no antidepressant medication in the preceding 3 months were identified at 23 collaborating centres from all over Japan (n=95). They were rated with the 17-item Hamilton Rating Scale for Depression (HRSD) and the Global Assessment Scale (GAS) monthly, and with the Social Adjustment Scale-Self Report (SAS-SR) 6-monthly. Remission was defined as 7 or less on the HRSD and recovery as 2 or more consecutive months of remission.
Results: The GAS ratings showed continuous amelioration from baseline to remission, remission to recovery, and after sustained recovery. The same trends were observed for SAS-SR scores.
Conclusion: We can expect further amelioration in social adjustment after symptomatic remission and recovery of major depressive episodes.
Document Type: Original Article
Affiliations: 1: Department of Psychiatry, Nagoya City University Medical School, Nagoya, Japan, 2: Department of Neuropsychiatry, Fukushima Medical University School of Medicine, Fukushima, Japan, 3: Health Science Center for Students, Miyazaki University, Miyazaki, Japan and 4: National Center for Neurology and Psychiatry, Tokyo and Chiba, Japan
Publication date: 2001-04-01