Augmentation with sulpiride for a schizophrenic patient partially responsiveto clozapine

Authors: Stubbs, Jean H.; Haw, Camilla M.; Staley, Christopher J.; Mountjoy, Christopher Q.

Source: Acta Psychiatrica Scandinavica, Volume 102, Number 5, November 2000 , pp. 390-394(5)

Publisher: Wiley-Blackwell

Buy & download fulltext article:


Price: $48.00 plus tax (Refund Policy)


Objective: Schizophrenic patients who are only partially responsive to clozapine pose a therapeutic challenge. In these circumstances some clinicians would consider adding in a second antipsychotic. We present a case report and review evidence for the efficacy of such augmentation strategies.

Method: Single case report and literature review.

Results: The total number of patients in studies and case reports of combining clozapine with other antipsychotics is small. There has been only one randomized controlled trial. This found the addition of sulpiride to clozapine resulted in clinical improvement in some patients.

Conclusion: Further randomized controlled studies of augmentation of clozapine therapy are needed to provide scientific justification for this clinical practice.

Keywords: antipsychotic; augmentation; clozapine; literature review; schizophrenia

Document Type: Case Report


Publication date: November 1, 2000

Related content



Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page