Neuromorphological abnormalities in schizophrenic patients with good andpoor outcome

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Objective: The present study was designed specifically to assess the relationship between brain morphology and outcome in schizophrenia. Methods: Fifty‐six schizophrenic patients and a matched group of 32 healthy subjects were studied with magnetic resonance (MR) imaging scans. Clinical assessment included the Krawiecka–Manchester Scale (K‐MS) and the Outcome scale by Strauss and Carpenter. Results: Along several neuromorphological measures the patients differed from controls only for right and left ventricular volumes. The ‘poor outcome’ patients had a left and right ventricular enlargement when compared to the ‘good outcome’ patients and healthy controls. A regression analysis showed that right ventricle volume, left temporal lobe volume and left hippocampal volume entered into the regression equation, accounting for a 27% of the outcome measure. Conclusion: The outcome does not seem to be predicted by one particular morphological site but involves different brain regions; however, the ventricular enlargement identifies a subgroup of patients with poor outcome.

Keywords: magnetic resonance; neuromorphological abnormalities; outcome; schizophrenia

Document Type: Original Article


Affiliations: 1: ‘Villa Serena’ Medical Center, Città S.Angelo (Pescara), Italy 2: MR Unit, University of L'Aquila, Italy, 3: Department of Psychiatry, S. Salvatore Hospital, L'Aquila, Italy and

Publication date: February 1, 2000

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