Corticolimbic changes in acetylcholine and cyclic guanosine monophosphate in the Flinders Sensitive Line rat: a genetic model of depression
Objective: Depression is suggested to involve disturbances in cholinergic as well as glutamatergic pathways, particularly the N‐methyl‐
Methods: Basal levels of nitrogen oxides (NOx) and both basal and
Results: Significantly elevated frontal cortical but reduced hippocampal ACh levels were observed in FSL versus FRL rats. Basal cGMP levels were significantly reduced in the frontal cortex, but not hippocampus, of FSL rats without changes in NOx and
Conclusions: These data confirm a bidirectional change in ACh in the frontal cortex and hippocampus of the FSL rat, as well as provide evidence for a frontal cortical ACh‐cGMP interaction in the depressive‐like behaviour of the FSL rat.
Document Type: Research Article
Affiliations: 1: Division of Pharmacology, Unit for Drug Research and Development, School of Pharmacy, North-West University, Potchefstroom, South Africa 2: Analytical Technology Laboratory, Unit for Drug Research and Development, School of Pharmacy, North-West University, Potchefstroom, South Africa 3: Centre for Psychiatric Research, University of Aarhus, Denmark
Publication date: 2012-08-01