Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population

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Abstract:

You J, Yuan Y, Shi Y, Zhang Z, Zhang X, Li H. Lack of association between BDNF Val66Met gene polymorphism and late-onset depression in a Chinese Han population. Background:

Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been suggested to be associated with major depressive disorder (MDD). There were a few reports of the relationship between the variant and late-onset depression (LOD) in Chinese Han population. Objective:

To investigate the relationship among BDNF Val66Met gene variants, BDNF plasma level and LOD. Methods:

Chinese Han patients with LOD (n = 99) and control subjects (n = 110) were assessed for BDNF Val66Met gene polymorphism. BDNF plasma level was tested only in LOD. Results:

There were no significant differences in genotypes and allele frequencies between cases and controls (p = 0.744 and p = 0.845, respectively). Plasma BDNF level also did not show significant differences in three genotypes in LOD (p = 0.860). Conclusion:

The Val66Met polymorphism in BDNF gene may not confer susceptibility to LOD in Chinese Han population.

Keywords: brain-derived neurotrophic factor (BDNF); gene; late-onset depression

Document Type: Research Article

DOI: http://dx.doi.org/10.1111/j.1601-5215.2009.00401.x

Affiliations: Department of Psychiatry, Nanjing Brain Hospital affiliated to Nanjing Medical University, Nanjing, 210029, China

Publication date: August 1, 2009

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