Skip to main content

Consequences of persistent pain after lung cancer surgery: a nationwide questionnaire study

Buy Article:

$51.00 plus tax (Refund Policy)



Post-thoracotomy pain syndrome (PTPS) and its social consequences have been inconsistently investigated as most studies were either small sized, focused on a limited number of risk factors or included heterogeneous surgical procedures. The current objectives were to obtain detailed information on the consequences of PTPS after thoracotomy and video-assisted thoracic surgery (VATS) from homogenous unselected nationwide data, and to suggest mechanisms for the development of PTPS. Methods:

Data from 1327 patients were collected using a prospective national database and combined with a detailed questionnaire. Results:

The response rate was 81.5%, resulting in 546 patients without prior thoracic surgery for the final analysis. Follow-up was 22 months (range 12–36). PTPS occurred in 33% thoracotomy patients and 25% VATS patients. Clinically relevant pain was present in 11–18% of the patients and severe pain in 4–12% depending on the level of physical activity. In PTPS patients, 64% also had pain from other locations on the body. Perceived sensory changes in the thoracic area were present in 63% of PTPS patients vs. 25% in pain-free patients (P<0.001). When comparing VATS with thoracotomy, no consistent differences in the prevalence, distribution of pain, sensory changes or effect of pain on daily activities were observed although clinically relevant and severe pain was reduced after VATS. Conclusions:

This nationwide study corroborates that PTPS is a clinically relevant problem influencing daily activities a long time after thoracotomy and VATS. Nerve injury and increased pain responsiveness may explain the majority of symptoms, the prevalence and distribution of pain including perceived sensory sensations.

Document Type: Research Article


Affiliations: 1: Thoracic Surgery, Rigshospitalet, Copenhagen University, Copenhagen, Denmark 2: Danish Lung Cancer Group, Odense University Hospital, Odense, Denmark 3: Danish Pain Research Centre, Aarhus University Hospital, Aarhus, Denmark 4: Section for Surgical Pathophysiology, Departments of

Publication date: 2011-01-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more