Authors: TORGERSEN, C.; SCHMITTINGER, C. A.; TAKALA, J.; JAKOB, S. M.; DÜNSER, M. W.

Source: Acta Anaesthesiologica Scandinavica, Volume 54, Number 8, September 2010 , pp. 1027-1035(9)

Publisher: Wiley-Blackwell

Abstract:

Background:

Currently, few data exist on the association between post-cardiac arrest hemodynamic function and outcome. In this explorative, retrospective analysis, the association between hemodynamic variables during the first 24 h after intensive care unit admission and functional outcome at day 28 was evaluated in 153 normothermic comatose patients following a cardiac arrest. Methods:

Medical records of a multidisciplinary intensive care unit were reviewed for comatose patients (Glasgow Coma Scale ≤9) admitted to the intensive care unit after successful resuscitation from an in- or an out-of-hospital cardiac arrest. The hourly variable time integral of hemodynamic variables during the first 24 h after admission was calculated. At day 28, outcome was assessed as favorable or adverse based on a Cerebral Performance Category of 1-2 and 3-5, respectively. Bi- and multivariate regression models adjusted for relevant confounding variables were used to evaluate the association between hemodynamic variables and functional outcome. Results:

One hundred and fifty-three normothermic comatose patients were admitted after a cardiac arrest, of whom 64 (42%) experienced a favorable outcome. Neither in the adjusted bivariate models (r², 0.61-0.78) nor in the adjusted multivariate model (r², 0.62-0.73) was the hourly variable time integral of any hemodynamic variable during the first 24 h after intensive care unit admission associated with functional patient outcome at day 28 in all patients as well as in patients after an in- or an out-of-hospital cardiac arrest. Conclusion:

Commonly measured hemodynamic variables during the first 24 h following intensive care unit admission due to a cardiac arrest do not appear to be associated with the functional outcome at day 28.

Document Type: Research article

DOI: http://dx.doi.org/10.1111/j.1399-6576.2010.02273.x

Affiliations: 1: Department of Intensive Care Medicine, Inselspital, Medical University of Bern, Bern, Switzerland

Publication date: 2010-09-01

Related content

• In this: publication
• By this: publisher
• In this Subject: Surgery
• By this author: TORGERSEN, C. ;  SCHMITTINGER, C. A. ;  TAKALA, J. ;  JAKOB, S. M. ;  DÜNSER, M. W.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers